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Optimal Opti-Nitric
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Optimal Opti-Nitric is the most advanced formula combining the amino acids L-arginine, ornithine and citrulline together to boost nitric oxide levels within the body. Optimal Opti-Nitric uses these amino acids to help with platelet reactivity and improving endothelial function. This is important to keep arteries and other blood vessels flexible and active. Nitric oxide is what the body uses to stimulate your blood vessels to expand and contract keeping blood pressure in check. L-citrulline is one of the three dietary amino acids in the urea cycle, alongside L-arginine and L-ornithine.
Individuals, both men and women, with poor circulation, high blood pressure, high cholesterol and many common health problems are often deficient in the critical molecule nitric oxide. With enough L-arginine, L-ornithine and L-citrulline, according to the research, you can reverse the deficiency and dramatically improve your cardiovascular and overall health.

The Journal of Advanced Research did an analysis on L-arginine studies that includes the amino acids ornithine and citrulline since they also work in the same pathway. Many human and animal studies have shown that when taken in the right dosages, these amino acids have multiple beneficial pharmacological effects such as reduction in the risk of vascular and heart diseases, reduction in erectile dysfunction, improvement in immune response and inhibition of gastric hyperacidity. The demonstrated anti-aging benefits of L-arginine, ornithine and citrulline show greater potential than any other nutraceutical agent ever previously discovered, according to the Journal. (Anti-aging effects of L-arginine, Cairo University , Journal of Advanced Research;17 June 2009; Dept. of Bichemistry, Faculty of Pharmacy and Biotechnology).
Research shows that L-arginine alone works great to improve nitric oxide levels in the body, especially in age groups under 30. After the age of 30, L-arginine’s effectiveness alone can be diminished because of oxidation and the bodies ability to use just the arginine pathway for nitric conversion. There are two ways to help with this problem. Optimal Opti-Nitric utilizes all three amino acids the body uses for this pathway and is why ornithine and citrulline are utilized.
This diagram shows the relationship of all three amino acids and why they are important to help with nitric oxide production.



SUSTAINED RELEASE is important for arginine to have long term benefits to circulation and stimulation. Special forms of arginine such as AAK are stabilized for sustained release.

Arginine, ornithine and citrulline have research showing that when taken orally in the right amounts can;

• Be a precursor for the synthesis of nitric oxide (NO). • Stimulate growth hormone for anti-aging benefits.
• Counter heart disease and aid in blood pressure
regulation.
• Improve insulin sensitivity to help normalize blood
sugar.
• Bolster the immune system, boost energy, and
increase lean muscle.
• Promote reproductive health.
• Be a natural alternative for Viagra.
• Increase fertility and pleasure sensation in women.
L-arginine, ornithine or citrulline are not hormones or testosterone. This is important knowledge for athletes. These are amino acids. When properly brought into the body they can cross the blood-brain barrier to signal the hypothalamus to naturally trigger the pituitary gland to produce growth hormone. This is the key to eliminating any negative side effects.

Columbia University refers to L-arginine as the “MAGIC BULLET” for the cardiovascular system. Columbia’s researchers have compiled over 10,000 citations and even include L-arginine in its course material.
DOSAGE IS EVERYTHING
Most arginine based supplements on the market don’t provide the amounts needed to induce nitric oxide (NO) responses. Doses of L-arginine, ornithine and citrulline vary based on the research studies examined. Typical daily doses for nitric oxide production and regulation of blood pressure range from 2-4,000 milligrams (2-4 grams). This is the amount needed to elicit the nitric oxide response. Each 2 capsule serving of Optimal Opti-Nitric contains 2 grams. Studies focusing on more serious acute conditions have utilized daily dosages from 6-9,000 milligrams. Consult with your physician for proper dosing.
NOTE ON CITRULLINE
Supplementing L-citrulline increases ornithine and arginine plasma content. This means L-citrulline supplementation improves the ammonia recycling process and nitric oxide metabolism. L-citrulline is also used to alleviate erectile dysfunction caused by high blood pressure. The other pathway that helps boost nitric oxide is the nitrate pathway. This pathway works at any age and when combined with Optimal Opti-Nitric makes for the most potent nitric oxide boost possible. Optimal Fruit and Veggie Plus has over 35 fruits and vegetables and has HUMAN CLINICAL STUDIES showing it boosts nitric oxide levels. Many people have nicknamed this combination as the “Nitric-Oxide Cocktail” because they take a serving of the fruit and veggie plus powder in drink form along with 4 Optimal Opti-Nitric capsules.

Studies on Arginine include:
u.a. Chen, J., Wollman, Y., Chernichovsky, T. et al: Effect of administration of high-dose nitric oxide donor Arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU International 83, 269-273, 1999. Zorgniotti, A.W., Lizza, E.F.: Effect of large doses of the nitric oxide precursor Arginine on erectile dysfunction. Int J Impotence Res 6, 33-36, 1994
“Stanislavov, R., et al, ”Treatment of erectile dysfunction with pycnogenol and L -arginine “, J Sex Marital Ther 2003 May-Jun, 29 (3 ), pp. 207-213”
Stühlinger & Stanger: Asymmetric DimethyL-arginine (ADMA): A possible link between homocyst(e)ine and endothelial dysfunction. Current Drug Metabolism, 2005, 6, 3-14 ”
“Bednarz B et al.: Efficacy and safety of oral Arginine in acute myocardial infarction. Results of multicenter, randomized, double-blind, placebo-controlled ARAMI pilot trial. Kardiol. Pol.. 2005,
62, 421-26 ”
Krause M et al.: Arginine is essential for pancreatic beta-cell functional integrity, metabolism and defense from inflammatory challenge; J Endocrinol. 2011 Jul 22
z.B. bei Shaheen E Lakhan, Karen F Vieira et al.: Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review; Lakhan and Vieira Nutrition Journal 2010, 9: 42
Williams, J.Z., Abumrad, N. & Barbul, A. (2002) Effect of a Specialized Amino Acid Mixture on Human Collagen Deposition, Annals of Surgery, Volume 236, issue 3, (pp. 369 – 375)
Lavie, L., Hafetz, A., Luboshitzky, R. & Lavie, P. (2003) Plasma levels of nitric oxide and L-arginine in sleep apnea patients, Journal of Molecular Neuroscience, Volume 21, issue 1, (pp. 57-63)
Merimee, T.J., Lillicrap, D.A. & Rabinowitz, D. (1965) Effect of arginine on serum-levels of human growth-hormone Lancet, Volume 2, issue 7414, (pp. 668-670)
Wu, G.A.B., Meininger, C.J., Knabe, D.A., Baze, F.W.A. & Rhoads, J.M. (2000) Arginine nutrition in development, health and disease, Current Opinion in Clinical Nutrition & Metabolic Care, Volume 3, issue 1, (pp. 59-66
Piatti, P.M., Monti, L.D., Valsecchi, G., Magni, F., Setola, E., Marchesi, F., Galli-Kienle, M., Pozza, G. & Alberti, K.G.M.M. (2001) Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients, Diabetes Care, Volume 24, issue 5, (pp. 875-880)
Ammann, P., Laib, A., Bonjour, J.-P., Meyer, J. M., Rüegsegger, P. & Rizzoli, R. (2002) Dietary essential aminoacid supplements increase the bone strength by influencing bone mass & bone microarchitecture in an isocaloric low-protein diet, Journal of Bone and Mineral Research, Volume 17, issue 7, (pp.1264-1272)

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