Poly-branched beta-1,3-D-glucan is a naturally occurring polysaccharide
derived from the cell walls of yeast (Saccharomyces cerevisiae).
Beta-1,3-D-glucan has been shown to act as a non-specific immune-activator.
Macrophages (immune cells) have receptor sites that bind to beta glucan. Once
bound to beta glucan the macrophage is activated. Macrophages are extensively
involved in everyday detoxifying processes, intestinal flora maintenance,
anti-infective and anti-tumor protection and maintenance of overall heath and
A novel type of immunotherapy for cancer uses beta glucan to override the
normal resistance of certain tumor cells to cytotoxic activation of macrophages
and natural killer cells allowing the immune system to function against the
1. Leonid Ber, MD, Yeast Derived Beta-1,3-D-Glucan: An Adjuvant Concept.
American Journal of Natural Medicine. Vo. 4, No.9, Nov. 1997
2. Ross, G, et al, Therapeutic intervention with complement and beta glucan
in cancer. Immunopharmacology, Volume42, Issues 1-3, May 1999, 61-74